The Restylane Range: Which Product Goes Where — And Why It Matters for Your Results

If you've ever stood in front of a patient, Restylane syringe in hand, and wondered whether you've chosen the right product for this face, this area, this goal — you're not alone. The Restylane range is one of the most comprehensive in aesthetic medicine. Eight products. Three distinct technologies. One overarching philosophy: results that look natural, not done.

But range breadth is only an advantage if you know how to navigate it.

This post breaks down the full Restylane portfolio — what each product does, where it belongs, and why product selection is the difference between a good result and a great one. 

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Why the Restylane Range Is Built Differently

Before we get into individual products, it helps to understand the science that separates Restylane from the competition.

Restylane products are built across three distinct technologies, each designed to work with the structural properties of a specific tissue layer:

NASHA HD™ and NASHA® — the backbone of the structural range. These are large-particle, high-G' gels designed for supraperiosteal and subcutaneous placement. High G' means high resistance to deformation — critical when you need projection, lift, and definition that holds. NASHA technology also has a significantly lower degree of HA modification than other popular portfolios, which means it behaves more like the body's own HA.

OBT™ (Optimal Balance Technology) — engineered for movement. OBT gels have the highest flexibility in the range, designed to integrate with soft tissue and move with natural facial expressions. Where NASHA provides structural architecture, OBT handles the dynamic zones where a rigid gel would show.

SB-NASHA™ — the skin quality platform. A microparticle formulation designed for intradermal delivery, not volumisation. This is Skinboosters: the original HA skin quality injectable, with a 15-month clinical evidence base behind it.

Together, these technologies cover the entire facial canvas — from supraperiosteal bone to mid-dermis — which is what makes multilayering with Restylane not just possible, but clinically logical.

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The Full Range: Product by Product

Restylane LYFT™ — For Lift Without Volumising

LYFT is the workhorse of the NASHA structural range. Firm gel, very high lifting capacity, supraperiosteal placement. It's your go-to for cheeks, nose, chin, jawline, and piriform fossa — areas where you need projection and definition rather than volume. Used with a 27G needle or 23–25G cannula, LYFT gives you precision architecture in the mid and lower face.

Best for: Structural cheek projection, non-surgical rhinoplasty, jawline definition, piriform fossa augmentation

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Restylane EYELIGHT™ — For a Brighter Periorbital Result

EYELIGHT is purpose-built for the infraorbital zone — one of the most technically demanding treatment areas in facial aesthetics. The formulation has lower water uptake than comparator gels, which is critical under the eyes where even minor swelling creates visible puffiness. The 0.5 mL syringe is optimised for this area, and clinical data shows results lasting up to 18 months with a noticeably refreshed appearance.

Best for: Infraorbital hollows, tear trough correction

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Restylane SKINBOOSTERS™ — Skin Quality, Not Volume

Skinboosters are a category of their own. The only HA skin quality injectable clinically proven to improve six measurable aspects of skin quality — deep hydration, smoothness, skin tone evenness, pore size, fine lines, and scarring — for up to 15 months. The SB-NASHA microparticle formulation activates biorevitalisation from within, stimulating native HA, collagen, and elastin production rather than simply adding volume.

VITAL is for regular to thicker skin, VITAL LIGHT for thinner and more delicate skin. Both use the unique SmartClick™ syringe, which delivers precise microdroplet injections with an audible dosage indicator — a genuinely meaningful innovation for consistent, safe technique.

Injectors have voted Skinboosters their number one choice for HA skin quality enhancement. The results speak for themselves.

Best for: Face, neck, décolletage, hands — skin health and glow rather than structural correction

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Restylane DEFYNE™ — For Defining

DEFYNE sits at the softer end of the OBT range — moderately flexible gel, placed subcutaneously or supraperiosteally depending on area. It's designed for mid-face definition: NLFs, marionette lines, chin, and mental crease. Clinical studies demonstrate 100% naturalness preservation, and DEFYNE has been shown to move with facial expressions in dynamic assessment — which is the clinical standard that matters.

Best for: Nasolabial folds, marionette lines, chin, mental crease

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Restylane VOLYME™ — For Effortless Volume

VOLYME is the OBT volumiser. Flexible gel, very high volumising capacity, with the seamless tissue integration that the OBT technology delivers. It contours without rigidity — cheeks and temples are the primary targets, and the clinical data shows 100% natural-looking results in every published study. Up to 13% less product is needed compared with Juvéderm Voluma for equivalent outcomes.

Best for: Cheek augmentation, temple volumisation

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Restylane KYSSE™ — For Natural Lips

Injectors' number one choice for the lips. KYSSE is a flexible OBT gel placed in the vermillion lip submucosal tissue — designed to plump, soften, and enhance while moving naturally with all the micro-expressions the lips are responsible for. Clinical data shows 96% of patients agreed their lips looked natural, 100% were happy with their lip style, and 73% of partners agreed treated lips had a more kissable, natural feel. Up to 20% less product is needed versus Juvéderm Volbella, with results lasting 12 months.

Best for: Lip augmentation, lip shape, lip texture

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Restylane REFYNE™ — For Refining

REFYNE is the most flexible gel in the entire range. Mid-to-deep dermis placement, OBT technology, designed for the subtle work: mild NLFs, mild marionette lines, perioral lines. It integrates seamlessly into soft tissue and moves with natural expression — the right choice when the goal is softening rather than structural correction.

Best for: Mild NLFs, mild marionette lines, perioral lines

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What Multilayering Actually Means in Practice

The Restylane range isn't just a collection of individual products — it's a system designed to work together across tissue planes. A full-face treatment plan might use LYFT supraperiosteally for structural support, VOLYME subcutaneously for volume restoration, DEFYNE for dynamic line correction, and REFYNE in the mid-dermis for fine line softening. Each product placed in its correct layer, doing the job it was engineered for.

This is multilayering: matching product properties — firmness, flexibility, volumising capacity, injection depth — to the specific tissue plane and the specific clinical goal. It's not complicated when you understand the logic. But the logic has to be clear first.

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Three Reasons the Restylane Range Belongs in Your Practice

1. The broadest firmness-to-flexibility spectrum on the market. No other single portfolio covers the full continuum from the highest G' structural support down to the most flexible dynamic gel. That means fewer compromises in product selection.

2. Three decades of safety evidence. NASHA technology has published safety data on nearly 407,000 patients. The delayed complication rate is 0% mean incidence for NASHA products versus 0.9–3.8% with Juvéderm Vycross technology. That's not a marginal difference.

3. Lower product volumes, equivalent results. Across multiple comparative studies, Restylane products consistently achieved non-inferior or superior results with 12–20% less product volume than Juvéderm comparators. Better outcomes, better economics.

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Ready to Go Deeper?

Product knowledge is one thing. Knowing exactly how to deploy these products — which combinations work for which presentations, how to layer, where the clinical evidence sits for each indication — is what separates competent from exceptional.

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Filler Decoded: Multilayering & Mastering the Restylane Range

A free live webinar — 22 April 2025 at 7pm BST

Hosted by Dr Lara Watson (KOL, Galderma) and Dr Emmaline Ashley, this is a clinical deep-dive into the full Restylane range: product selection, area-specific indications, multilayering technique, and live Q&A with two of the most experienced voices in UK aesthetic medicine.

This isn't a sales presentation. It's the kind of product training that actually changes how you treat.

Attend live and unlock exclusive Restylane pricing — available to registered attendees only.

Free to attend. Limited spaces.

[Register now ]

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Products available through Harley Supplies. For healthcare professionals only. Always refer to the individual product IFU for full prescribing and safety information.