If you work in aesthetic medicine, you’ve probably heard the buzz around polynucleotides. Touted as the next big thing in skin regeneration, they’re quietly redefining what we expect from non-surgical treatments. But beyond the hype, what are they really? And more importantly—how, when, and why should you use them in clinical practice?
This guide cuts through the noise to provide a clear, clinician-focused overview of what polynucleotides are, how they work, and where they fit in the growing field of regenerative aesthetics.
What Are Polynucleotides?
Polynucleotides are linear chains of nucleotides—the fundamental building blocks of DNA and RNA. In aesthetic medicine, they are typically derived from highly purified salmon DNA and used to stimulate tissue repair and skin regeneration.
Unlike traditional skin boosters or fillers that volumise or hydrate directly, polynucleotides act as biostimulants. They trigger cell signalling pathways, reduce oxidative stress, and stimulate fibroblast activity, ultimately enhancing collagen and elastin synthesis.
Mechanism of Action
Polynucleotides work by:
- Scavenging free radicals and reducing oxidative stress in the dermis
- Activating fibroblasts to promote collagen and elastin production
- Improving hydration through increased glycosaminoglycan synthesis
- Supporting wound healing and tissue repair, especially in stressed or ageing skin
The result? Healthier, denser, more elastic skin over time. While the effects are subtle and gradual, the biological improvements are measurable and long-lasting.
Indications for Use
Polynucleotides are suitable for:
- Periorbital rejuvenation(especially in patients unsuitable for HA filler)
- Early signs of ageing
- Sun-damaged or post-inflammatory skin
- Scarring and texture concerns
- Skin prep for lasers or energy-based treatments
They are often used in a series of treatments, spaced 2–4 weeks apart, with top-ups every 6 months depending on patient age and skin quality.
Product Format and Administration
Most polynucleotide products come in pre-filled syringes or vials and are administered intradermally or via micro-papular injection technique. Some may also be used with microneedling or mesotherapy protocols.
Storage and transport are crucial—many require temperature control and must be used within a specific time once opened.
Are They Safe?
Yes, when sourced from reputable, medical-grade suppliers, polynucleotides have an excellent safety profile. They are biocompatible, non-immunogenic, and well tolerated, with minimal risk of Tyndall effect or nodules.
As always, correct patient selection and technique matter. While safe, they are not a one-size-fits-all solution.
How Do They Compare to Other Injectables?
| Category | Mode of Action | Main Use |
| Hyaluronic Acid | Hydration & volume | Volumisation, fine lines |
| Biostimulators | Collagen stimulation | Long-term skin regeneration |
| Polynucleotides | Regeneration + repair | Elasticity, healing, dermal quality |
Polynucleotides are best thought of as a foundation-layer treatment: regenerative and subtle, but capable of transforming overall skin quality when used correctly.
Final Word: Why Clinicians Are Taking Notice
As patient expectations shift towards natural, long-term results, polynucleotides offer a powerful solution. They don’t replace fillers or toxins, but they support the skin from within, creating the conditions for more harmonious and resilient outcomes.
For clinicians focused on evidence-based, regenerative aesthetics, polynucleotides are more than a trend. They’re the start of a new chapter in injectable skincare.