Milk-derived exosomes represent an innovative breakthrough in aesthetic medicine, offering practitioners and patients alike a promising avenue for enhancing treatment outcomes. Increasingly, clinicians are exploring ways to maximise results from minimally invasive procedures such as microneedling, and milk-derived exosomes have emerged as a highly effective adjunct.
What are exosomes?
Exosomes are tiny nanovesicles secreted by cells, essential for intercellular communication.
Milk exosomes, particularly those from bovine sources, have unique benefits due to their resilience and compatibility with human skin. Unlike many alternatives, milk exosomes maintain their integrity even in acidic environments, allowing them to reach deeper skin layers effectively.
What does the research show?
One notable study conducted by Dr. Marcello Polini and colleagues explored the use of ReversHA - milk exosomes combined with active ingredients like polynucleotides (PDRN), hyaluronic acid (both high- and low-molecular-weight), biomimetic oligopeptides, glutathione, amino acids, and niacinamide.
Conducted with 30 healthy patients (20 women and 10 men, aged between 40 and 60), the study involved four treatments spaced two weeks apart, applying 2.5ml of the exosome solution per facial zone using a microneedling pen set to a depth of 0.3mm. Results demonstrated significant improvements, with 85% of participants reporting increased skin brightness, hydration, lifting effects, visibly reduced pores, and noticeable wrinkle reduction. Moreover, 85% of participants reported being satisfied, and 90% expressed willingness to repeat the treatment in the future.
Why milk-derived exosomes?
One reason milk-derived exosomes excel is their ability to efficiently transport potent skin-enhancing ingredients into deeper dermal layers. The combination of milk exosomes with polynucleotides and hyaluronic acid enhances collagen and elastin production, providing regenerative effects. Additionally, glutathione and niacinamide included in the formulation significantly contributes to skin brightening and antioxidative protection, supporting anti-ageing effects and reducing hyperpigmentation.
Further advantages are provided by their natural biocompatibility and non-immunogenic nature, meaning they rarely provoke immune responses, making treatments safer and broadly applicable across diverse patient groups. Moreover, milk-derived exosomes have demonstrated the ability to withstand acidic environments, ensuring their efficacy when penetrating deeper skin layers, where they facilitate collagen regeneration and cellular repair.
How are they used?
Clinically, microneedling treatments combined with milk-derived exosomes target key aesthetic concerns such as wrinkles, dehydration, enlarged pores, and skin dullness. These treatments activate natural healing processes, stimulating collagen production (neocollagenesis) and encouraging neovascularisation, resulting in firmer, younger-looking skin.
Final Thoughts
In conclusion, integrating milk-derived exosome therapies into aesthetic practice presents an exciting opportunity for clinicians to enhance treatment outcomes and patient satisfaction. With demonstrated clinical effectiveness, safety, and patient approval, milk-derived exosome solutions offer a powerful and innovative approach to anti-ageing and regenerative skincare. As aesthetic medicine continues to evolve, embracing cutting-edge solutions like milk exosomes will be instrumental in setting practices apart and delivering exceptional results.